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New study identifies brain changes which explain why sleep apnea increases risk for developing Alzheimer’s

Researchers working on the EU-funded Silver Santé Study have identified brain changes which explain for the first time why sleep apnea increases the risk of developing Alzheimer’s.

The research, led by Dr Géraldine Rauchs , of Inserm, in Caen, France, was published in JAMA Neurology (https://bit.ly/33HxOIB )

Dr Rauchs and her team studied the effects of sleep apnea on 127 older adults who were taking part in the Age Well clinical trial of the Silver Santé Study. The volunteers, with a mean age of 69, completed neuropsychological assessments (tests to assess how the brain is working), polysomnography (to assess sleep quality and potential sleep disorders) tests and neuroimaging scans.

Those participants with sleep-disordered breathing (SDB or types of sleep apnea) showed greater amyloid burden (protein deposits in the brain), GM volume (number of brain cells) and metabolism (how these cells use glucose for their activity) in brain areas particularly vulnerable to Alzheimer’s – increasing their risk of developing the disease in coming years. No association was found with cognition, self-reported cognitive and sleep difficulties or excessive daytime sleepiness symptoms.

Dr Rauchs, the paper’s author, says: “The results are very significant as although there was increased evidence suggesting sleep-disordered breathing (SBD) increases the risk of developing Alzheimer’s, the brain mechanisms underlying the link were unclear.

“This study shows for the first time that SBD, or sleep apnea, increases amyloid burden, GM volume and metabolism in brain areas particularly vulnerable to Alzheimer’s disease, increasing the risk of these individuals developing the disease in the future. This doesn’t mean, of course, that these participants will necessarily develop Alzheimer’s – just that their risk of developing the disease in future is increased.

“Fortunately, there are effective treatments available for SDB but the results of this study re-emphasize the importance of preserving good sleep quality throughout life in order to safeguard good mental health in later life.”

The results of the Silver Santé Study’s two clinical trials are due to be released later this year.

A volunteer has special headgear fitted by a researcher to monitor their sleep at Inserm in Caen, France.

Funds sought to add 21-month follow-up to Age Well trial

Silver Santé Study researchers are exploring funding opportunities to allow them to add a 21-month post intervention analysis to the Age Well clinical trial.

All 137 volunteers, bar two, have agreed to take part in additional follow-up tests at 21 months to further strengthen validation of the trial by studying whether the effects of mental training techniques persist over time.

After taking part in a series of baseline tests at the beginning of each wave, the volunteers were randomly assigned to one of three groups – an English language course, a meditation course, or a control group that had no intervention.

Blood tests, neuroimaging scans and questionnaires have been used by our expert researchers to assess the impact of the mental training techniques on the brain. The volunteers’ lifestyle habits – such as sleep, diet, physical exercise and emotions – have also been monitored.

The results of the Age-Well trial are expected to be released later this year.

Volunteers taking part in an English class as part of the Age Well trial

Project researchers to present results at prestigious Alzheimer’s conference

Senior researchers from the Silver Santé Study will be presenting the key findings of the project at the prestigious Alzheimer’s Association International Conference (AAIC) in July.

The teams will gather in Amsterdam from 26-30 July to present their analyses of the data collected from the project’s two major clinical trials – Age Well and SCD Well. Each year, the AAIC convenes the world’s leading basic science and clinical researchers, next-generation investigators, clinicians and the care research community to share research discoveries that’ll lead to methods of prevention and treatment and improvements in the diagnosis of Alzheimer’s disease.

Age Well is examining the impact of an 18-month intervention on healthy older adults aged 65+ in the Caen area of France and expert meditators. The volunteers were randomly assigned to one of three groups – meditation practice, foreign language learning, or a control group that had no intervention.

The SCD Well trial is assessing the impact of a short (8 week) course of either meditation or health education on patients from memory clinics in the UK, France, Spain and Germany.

Project Coordinator, Dr Gaël Chételat, who will be among those attending the conference, says: “As the world’s leading Alzheimer’s conference, the AAIC provides an invaluable opportunity for us to share our findings with the international scientific community.

“We look forward to doing so and to hearing from other scientists about their most recent findings in this important field of research.”

The AAIC conference takes place at the RAI Amsterdam, Europaplein 24, 1078 GZ Amsterdam, in the Netherlands.

The Silver Santé Study consortium pictured at the project’s 2019 annual consortium meeting in Berlin.

What is meditation?

By Martine Batchelor

(posted 12th December 2019)

Meditation – along with language-learning and health education – is one of the mental training activities being trialled in the Silver Santé Study to assess its impact on mental health and well-being in the ageing population.

Although meditation – or mindfulness – is now commonly referred to in everyday life, there are many misconceptions about what it is. One, for example, is that meditation is about clearing the mind of all thought. Another is that meditation is a religious practice. While most religions involved some kind of contemplative study, like meditation, the meditation studied in the Silver Santé Study is entirely secular and, while based on Buddhist meditation, it has been adapted especially for potential use for medical purposes.

Rather than clearing the mind of thought, meditation is about cultivating certain qualities that we already have but to a greater degree. One of the bases of meditation is to cultivate focusing, concentration, and anchoring and this means that you are given something to focus on – such as the breath, the body, a sound, or a question. Should your mind wander and start thinking about other things, you simply bring your thoughts back to what you were focusing on and you do this with a positive, friendly attitude. Each time your thoughts wander, you bring them back to what you were focusing on. So both elements are important – the technique, i.e. the focusing, and the attitude with which you do it, i.e. in a friendly way. Once you cultivate the focusing element, it helps you to become calmer.

It’s also important to remember that the aim is not to become the greatest meditator, it’s about helping us become calmer, clearer and more compassionate in daily life.

There are different types of meditation. Mindfulness, for example, is where you focus on something like the breath, the body, a sound, feeling or mental state and then you keep coming back to it in a friendly way. With that technique, it’s about being aware of the change of the breath, the change of sensation, etc. There are other types of meditation too – some focus on a question, while others, like loving kindness meditation, focus on being compassionate to oneself and to others. There are types that are reflective and others that focus on repeating phrases.

Meditation is suitable for most people to some degree.  It’s just like sport – it’s generally good for most people but not suitable for everyone. There are very few negative effects associated with meditation as long as it’s in light conditions. For example, a 7-day silent retreat is not suitable for everyone, but a weekly two-hour mindfulness session every week should be fine for most people.

My advice to anyone wanting to try out meditation would be to find a local course to get some guidance, and then to practice it regularly to see some benefit. Some people find that meditating 10 minutes each day works for them but others meditate for longer – whatever suits you best. It’s also worth mentioning that you don’t need to be sitting down to meditate, you can do it walking, standing, sitting or lying down.

Watch Martine explain meditation in our short video:

 

Could brain training keep our cells younger?

By Dr Perla Kaliman

(Posted 27th June 2019)

In an experiment involving identical twins, who would age faster: the twin who is placed in a high-speed rocket and travels near the speed of light or the twin who remains earthbound?

While studying this dilemma known as “the twin paradox,” Albert Einstein guessed that the date of birth is not enough to know the biological age of a person. In 1918, within the framework of his theory of relativity, Einstein showed that when returning from his trip to the stars, the galactic twin would be younger than his sibling born on the same date and with the same DNA. What was unknown 100 years ago is that we don’t need a trip on a space shuttle to modulate our cell ageing. Current research shows that less than 25% of the variations in human longevity can be attributed to our inherited genetic information. It is now clear that the quality of ageing and longevity result from powerful interactions between genes, environment, lifestyle and experiences.

Objectively we can talk about chronological age and biological age. The chronological age is calculated from our date of birth, while the biological age can be measured on our chromosomes. And they do not always match. There are repetitive DNA structures at the end of the chromosomes, called telomeres, whose function is to protect the genetic material. They fulfill a similar task to that of the ends of the shoe laces, that is, to prevent the DNA from fraying and damaging. With age, as part of a natural process, the telomeres get shorter. When the telomeres are already too short to efficiently carry out their protective functions, the cells lose their capacity for division, a phenomenon that increases the risk of most chronic age-related diseases i.e. cardiovascular disease, metabolic syndrome. Conversely, numerous studies indicate that longer telomeres predict long-term health. It has also been proven that the cells of centenarian people who are in good health have telomere lengths that correspond to younger chronological ages.

Recent research suggests that lifestyle-related factors influence the rate of biological ageing (i.e. nutrition, stress, quality of sleep, physical activity, education, social environment). In the Silver Santé Study, part of our work aims to identify lifestyle factors that may influence the rate of biological ageing. In order to do this, we collected blood samples from all the participants at the beginning of the Age-Well clinical trial and we are now obtaining a second sample from all of them at the end of mental training interventions. Our hypothesis is that brain training activities such as meditation and foreign language-learning may help to slow down the pace of the biological ageing. We very much look forward to learning and sharing the results of our study that may contribute to revealing the molecular mechanisms of long-term brain training on healthy ageing and may help in the design of preventive strategies for age-related chronic diseases.

Learning a second language and its impact on brain health and well-being in seniors

By Caitlin Ware

(posted 1st October 2019)

The adult brain can change and grow as a result of learning[1], even in later life.[2]

It is thought that learning a second language could be a very promising and dynamic way of improving cognitive capacities and maintaining the brain’s functions, as both structural and functional neurological differences have been observed in bilinguals compared to people who only speak one language (monolinguals).

These brain differences may determine how the brain ages and compensates for pathology.[3] What is more, bilingualism and multilingualism have been shown to contribute to a delay in the onset of dementia in seniors.[4]

Although remaining a subject of hot debate[5], research has shown that bilingualism seems to strengthen certain cognitive processes, constituting a ‘bilingual advantage.’ Compared to monolinguals, bilinguals have demonstrated higher scores on cognitive tests, especially those measuring attention and mental control.

Some neuroanatomical and functional changes have been associated with foreign language learning, such as the growth of certain brain regions, and a better connectivity between them. This is promising in the context of ageing, as the brain tends to lose its volume and connectivity with time.[6]

Although research in language learning has focused mainly on children and young adults, a few studies have concentrated on the effects of second language learning in seniors. Not only has it been shown to be feasible and beneficial from a subjective point of view[7], research has shown that it can strengthen cognitive functioning, as well as psychological well-being and quality of life.[8] Moreover, a recent study has evidenced increased connectivity between certain brain regions of Italian older adults learning English after only four months of training.[9] Indeed, learning a foreign language is an intense intellectual activity, which involves memory and attention.

Learning a second language can also engage communication, travel, and involvement in the community, providing seniors with an outlet to improve their overall well-being and sense of confidence. More studies are needed involving larger groups and a longitudinal design and the Silver Santé study is the first to carry out such research. With a language-learning intervention of 18 months, Silver Santé is the longest ever study of its kind and it will be fascinating to see what impact the course has on the mental health and well-being of its participants.

 

Sources: 

[1]Lövdén, M., Wenger, E., Mårtensson, J., Lindenberger, U., Bäckman, L. (2013) Structural brain plasticity in adult learning and development. Neuroscience Biobehavioral Review,37, 2296-310. doi: 10.1016/j.neubiorev.2013.02.014.

[2] Pauwels, L., Chalavi, S., Swinnen, S. (2018) Aging and Brain plasticity. Aging (Albany) 10(8), 1789–1790. doi: 10.18632/aging.101514

[3] Bialystok, E., Abutalebi, J., Bak, T.H., Burke, D.M., Kroll, J.F., (2016) Aging in two languages: Implications for Public Health. Ageing Res Rev, 27, 56–60. doi:10.1016/j.arr.2016.03.003.

[4] Perani, D., Abutalebi, J. (2015) Bilingualism, Dementia, Cognitive and Neural Reserve. Curr Opin Neurol, 28, 618–625. DOI:10.1097/

[5] García-Pentón, L., Fernández García, Y., Costello, B., Andoni Duñabeitia, J., Carreiras, M. (2016) The neuroanatomy of bilingualism: how to turn a hazy view into the full picture. Language, Cognition and Neuroscience, 31:3, 303-327. DOI: 10.1080/23273798.2015.1068944

[6] Siman-Tov, T., Bosak, N., Sprecher, E., Paz, R., Eran, A., Aharon-Peretz, J., Kahn, I. (2017) Early Age-Related Functional Connectivity Decline in High-Order Cognitive Networks. Front. Aging Neurosci. 8:330, 1-17. doi: 10.3389/fnagi.2016.00330

[7] Ware, C., Damnee, S., Djabelkhir, L., Cristancho, V., Wu, Y.-H., Benovici, J., Pino, M., Rigaud, A.-S. (2017) Maintaining Cognitive Functioning in Healthy Seniors with a Technology-Based Foreign Language Program: A Pilot Feasibility Study. Front. Aging Neurosci. 9:42. 1-10. doi: 10.3389/

[8][ Pfenninger, S. E., Polz, S. (2018). Foreign language learning in the third age: A pilot feasibility study on cognitive, socio-affective and linguistic drivers and benefits in relation to previous bilingualism of the learner. Journal of the European Second Language Association, 2(1), 1–13. DOI:http://doi.org/10.22599/jesla.36

[9] Bubbico, G., Chiacchiaretta, P., Parenti, M., di Marco, M., Panara, V., Sepede, G., Ferretti, A., Perrucci, M.G. (2019) Effects of Second Language Learning on the Plastic Aging Brain: Functional Connectivity, Cognitive Decline, and Reorganization. Front. Neurosci. 13:423, 1-13. doi: 10.3389/fnins.2019.00423

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